Overactive Adrenal Glands/Cushing's Syndrome
What are overactive adrenal glands?
When adrenal glands produce excessive amounts of certain hormones, they are called "overactive." Symptoms and treatment depend on which hormones are being overproduced:
Androgenic steroids (androgen hormones). An overproduction of androgenic steroids, such as testosterone, can lead to exaggerated male characteristics in both men and women, such as hairiness of the face and body, baldness, acne, deeper voice, and more muscularity.
Corticosteroids. An overproduction of corticosteroids can lead to Cushing's syndrome (see below).
Aldosterone. An overproduction of the aldosterone hormone can lead to high blood pressure and to those symptoms associated with low levels of potassium, such as weakness, muscle aches, spasms, and sometimes paralysis.
The symptoms of overactive adrenal glands may resemble other conditions or medical problems. Always consult your doctor for a diagnosis.
How are overactive adrenal glands diagnosed?
In addition to a complete medical history and medical examination, diagnostic procedures for overactive adrenal glands may include:
Specific blood tests to measure levels of hormones
Urine tests to measure levels of hormones
Radiologic tests, such as computed tomography (CT) scan, magnetic resonance imaging (MRI), ultrasound, or X-ray
What is the treatment for overactive adrenal glands?
Treatment of overactive adrenal glands depends on the cause of the disease and source of the overproduction of cortisol.
Treatment may include surgical removal of growths or the adrenal gland(s) itself. If external steroid use is determined to be the cause, gradual tapering and removal of the steroid may be recommended. Certain drugs that block the excessive production of certain hormones may also be administered.
What is Cushing's syndrome?
Cushing's syndrome is the result of excessive corticosteroids in the body. The main cause is overproduction of adrenocorticotropin hormone (ACTH) in the pituitary gland. ACTH causes the adrenal glands to produce corticosteroids, so too much of ACTH means too much of corticosteroids. Another main cause is taking long-term external steroids like prednisone (sometimes used in some chronic diseases). In addition, certain lung cancers and other tumors outside the pituitary gland may produce corticotropins. Other causes include benign or cancerous tumors on the adrenal glands. Rarely, Cushing syndrome can be an inherited endocrine disorder.
What are the symptoms of Cushing's syndrome?
The following are the most common symptoms of Cushing's syndrome. However, each individual may experience symptoms differently. Symptoms may include:
Upper body obesity
Increased fat around neck or a fatty hump between the shoulders
Thinning arms and legs
Fragile and thin skin
Stretch marks on abdomen, thighs, buttocks, arms, and breasts
Bone and muscle weakness
High blood pressure
High blood sugar
Irritability and anxiety
Excess facial and body hair growth in women
Irregular or stopped menstrual cycles in women
Reduced sex drive and fertility in men
The symptoms of Cushing's syndrome may resemble other conditions or medical problems. Always consult your doctor for a diagnosis.
How is Cushing's syndrome diagnosed?
In addition to a complete medical history and medical examination, diagnostic procedures for Cushing's syndrome may include:
24-hour urinary test to measure for corticosteroid hormones
Computed tomography (CT or CAT scan). A noninvasive diagnostic procedure that uses a combination of X-rays and computer technology to produce horizontal, or axial, images of the body. to detect any abnormalities that may not show up on an ordinary X-ray.
Magnetic resonance imaging (MRI). A noninvasive procedure that produces two-dimensional views of an internal organ or structure.
Dexamethasone suppression test. This test differentiates whether the excess production of corticotropins are from the pituitary gland or tumors elsewhere.
Corticotropin-releasing hormone (CRH) stimulation test. This test differentiates whether the cause is a pituitary tumor or an adrenal tumor.
Other laboratory tests
What is the treatment for Cushing's syndrome?
Treatment for Cushing's syndrome depends on its cause. Surgery may be needed to remove tumors or the adrenal glands. Other treatment may include radiation, chemotherapy, and use of certain hormone-inhibiting drugs.